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. 2005 Jul 4;202(1):135–143. doi: 10.1084/jem.20050500

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Copyright © 2005, The Rockefeller University Press

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Figure 5. — IFN-α/β signaling is required for the development of psoriatic skin lesions. Human CD3⁺ T cell count (a) and papillomatosis index in skin grafts before transplantation (uninvolved prepsoriatic skin at day 0) and 35 d after transplantation subsequent to the administration of isotype-matched control Ab or neutralizing anti–IFN-α/β receptor mAb (b). Values of primary psoriatic plaques derived from the graft donors are provided in comparison. Error bars in panel a represent one SD. Dots in panel b represent independently grafted mice or patient samples. p-values calculated by the unpaired Student's t test are indicated.