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. 2005 Jul 4;202(1):157–168. doi: 10.1084/jem.20050559

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Copyright © 2005, The Rockefeller University Press

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Figure 4. — N1 activation enhances SKP2 expression and p27^Kip1 degradation during cell cycle progression. (A) Immunoblot of SKP2 and p27^Kip1 during cell cycle progression induced by nocodazole block and release. (B) SKP2 expression at 6 h from nocodazole block and release was quantified by densitometric analysis and normalized with β-actin expression in Western blots of three independent experiments. Bars express average fold increase of SKP2 expression in ΔE cells compared with GFP. (C) Bars represent average percentage of p27^Kip1 expression at 6 h relative to 2 h (100%) in four independent experiments. (D) Immunoblot of SKP2, p21^Cip1, and p27^Kip1 during serum-induced cell cycle progression.