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. 2005 Jul 4;202(1):73–84. doi: 10.1084/jem.20050198

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Copyright © 2005, The Rockefeller University Press

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Figure 1. — Mice with extremely limited and partially limited MHC peptide repertoires are prone to autoimmunity. (A) Histologic examination of organs from A^bEp mice >6-mo-old revealed mononuclear infiltrates in different organs. (B) Lymphoid infiltrates around a large peritoneal blood vessel (top left), and a pancreatic islet (right and bottom left). Hematoxylin-eosin staining (top), anti–CD4-FITC (bottom left), and anti–CD8-FITC (bottom right). LN, lymph node. (C) ANAs in the sera of >5-mo-old A^bEp mice expressing Ii. Negative control B6 serum scored “0,” serum from B6^lpr/lpr mouse scored “10,” while a serum from a representative A^bEp,Ii⁺ mouse scored “5” on a relative scale. (D) Distribution of ANA presence and titers in A^bEp,Ii⁺ mice and control mice. All data are for sera dilution of 1:50.