Figure 3.

MM14.4 CD8⁺ T cells are responsible for the psoriasiform dermatitis. (A) CD8⁺ cells were found to infiltrate the epidermis (cryostat section, stained with anti-CD8 antibodies coupled to FITC; a 20× Fluotar objective). (B) Treatment of MM14.4 transgenic mice (strain 690) with anti-CD8 monoclonal antibodies decreased the relative dermatitis score (± SE). (C) Skin DCs isolated from A^bEp or MHC class II–negative C2Δ mice, but not their splenocytes, triggered proliferation of purified CD8⁺ cells from 690 transgenic Rag-1–deficient mice. B10.BR (H-2^k) cells were used as positive control because MM14.4 CD8⁺ cells have a strong alloreactivity to H2-K^k molecules. Combined data from two experiments.