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. 2005 May 16;201(10):1555–1565. doi: 10.1084/jem.20042521

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Copyright © 2005, The Rockefeller University Press

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Figure 5. — Continued proliferation of CD4⁺ T cells depends on antigen persistence. (A) CFSE-labeled lymph node cells from CD45.1⁺ AND TCR transgenic mice were transferred into mice that were treated with 100 μg/ml dox for 24 h according to the indicated schedules. All recipients were double transgenic Ii-rTA⁺TIM⁺, except mouse 1, which carried the TIM gene only and was dox treated throughout. Subcutaneous lymph nodes were removed 36, 60, 84, and 108 h after transfer and were analyzed by flow cytometry. The 36-h and 60-h panels are gated on CD4⁺ cells, the others on CD4⁺CD45.1⁺ cells. One representative experiment out of five independent ones is shown. (B) Mean number of divisions of transferred cells from experiment A plotted against time is shown. (C) Proportion of transferred AND CD4⁺ cells among total CD4⁺ cells in subcutaneous lymph nodes from experiment A over time is shown.