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. 2005 May 16;201(10):1677–1687. doi: 10.1084/jem.20042081

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Copyright © 2005, The Rockefeller University Press

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Figure 3. — Ikkβ^D, but not Ikkα^AA, mice are osteopetrotic. (A) Sections of the metaphyseal regions of the proximal tibia of 4-mo-old WT, Ikkα^AA, and Ikkβ^Δ mice were subjected to H&E staining. (B) Decreased numbers of TRAP-positive (red-stained) multinucleated cells below the growth plate of Ikkβ^Δ mice. TRAP-positive cells are marked by arrows. (C) Histomorphometric analysis of structural bone parameters in Ikkβ^Δ (n = 6), Ikkα^AA(n = 6), and F/F (Ikkβ^F/F, n = 6 ) mice at 4 and 7 mo of age. OcS/BS, osteoclast surface/bone surface; NOc/B.Pm, number of osteoclasts/bone perimeter/mm; Tr.Th, trabecular thickness (mm); Tr.N trabecular number/mm; Tr.S, trabecular separation/mm³; NOb/B.Pm, number of osteoblasts/bone perimeter/mm; ObS/BS, osteoblast surface/bone surface; MAR, mineral apposition rate. *P < 0.05.