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. 2005 May 16;201(10):1647–1657. doi: 10.1084/jem.20041044

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Copyright © 2005, The Rockefeller University Press

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Figure 6. — CD103 expression promotes destruction of the host intestinal epithelium by CD8⁺ T cells during GVHD. Lethally irradiated BALB/c (H-2^d) hosts were adoptively transferred with 10 × 10⁶ B6 BMC alone or in combination with 10 × 10⁶ CD8-enriched SC from either wild-type or CD103^−/− mice on the B6 (H-2^b) background. (A) Survival of recipients of B6 BMC alone (dashed line, n = 4), or in combination with CD8⁺ T cells from wild-type (dotted line; MST = 8.2 ± 0.8 d, n = 11) or CD103^−/− (continuous line; MST > 48.6 ± 6.5 d, n = 10) donors (P < 0.001). (B) Representative H&E sections of intestinal specimens at day 14 after BMT from recipients of wild-type (left) or CD103^−/− (right) CD8⁺ T cells, at low (top, 20×) and high (bottom, 40×) magnification. Arrows denote apoptotic bodies. (C) Representative H&E sections of liver specimens at day 14 after BMT in recipients of wild-type (left) or CD103^−/− (right) CD8⁺ T cells (magnification, 20×).