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. 2005 Sep 19;202(6):761–769. doi: 10.1084/jem.20050193

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Copyright © 2005, The Rockefeller University Press

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Figure 6. — Defects in pulmonary host defense in IL-23 p19^−/− mice are rescued by IL-17 treatment. WT C57BL/6 or IL-23 p19^−/− mice were challenged with 10⁴ K. pneumoniae followed by intratracheal administration of 1.5 μg recombinant murine IL-17 (or phosphate-buffered saline vehicle) 12 h later. Animals were then killed 24 h after rmIL-17 (or vehicle) delivery. (A) IL-17 improves bacterial clearance in IL-23 p19^−/− mice. (B) IL-17 restores pulmonary concentrations of G-CSF, KC, and LIX in IL-23 p19^−/− mice. (C) IL-17 partially improves bacterial clearance in IL-12 p40^−/− mice. *P < 0.05 compared with WT vehicle-treated control. **P < 0.05 compared with vehicle-treated group of same genotype (n = 4–6 per group). Error bars represent mean ± SD.