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. 2005 Nov 21;202(10):1411–1422. doi: 10.1084/jem.20051089

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Copyright © 2005, The Rockefeller University Press

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Figure 5. — B cells with an altered phenotype can be detected in conditional PU.1 knockout mice and increase with the age. (A) FACS plots of the bone marrow, spleen, and blood leukocytes in a control and a conditional knockout mouse at 6 mo old. The plots show B220 versus EYFP expression. Arrows indicate the EYFP^bright plasma cells in the control and the knockout spleen. Histograms show levels of CD43 expression of EYFP⁺ cells within the gates indicated in green for B220⁺ control cells; in blue for B220⁺ knockout cells; and in red for B220^low knockout cells. (B) FACS plots of the peripheral blood of PU.1 knockout mouse 25 at 1, 5, 9, and 12 mo old. (C) Histogram summarizing the proportion of B220^lowEYFP⁺ cells in EYFP⁺ B cell population within the peripheral blood in control (white bars) and knockout mice (black bars) at different age. Error bars represent means ± standard deviations. The numbers of mice analyzed are indicated.