Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Jul 18;202(2):321–331. doi: 10.1084/jem.20050338

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2005, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 5. — Lymphadenopathy, hypergammaglobulinemia, and lymphocyte accumulation in TLR-deficient mice. TLR9^+/+ (n = 19), TLR9^−/− (n = 16), TLR3^+/+ (n = 15), and TLR3^−/− (n = 17) mice were killed at 20 wk of age and assessed for evidence of aberrant immune activation; nonautoimmune C57BL/6 control mice (n = 4) were killed at 26 wk of age. (A) Spleens and the two largest axillary lymph nodes were removed and weighed. (B) Total serum IgG and IgG2a were determined. (C) Splenocyte subsets were enumerated by FACS analysis for T cells (Thy1.2⁺), DNTC (CD4⁻/CD8⁻ double-negative T cells), and B cells (CD22⁺). (D) Splenic CD4⁺ T cells were classified as either naive (CD44⁻ CD62L⁺), activated (CD44⁺ CD62L⁺), or memory (CD44⁺ CD62L⁻) phenotype. The analysis in D was performed on 12 TLR3^+/+ and 12 TLR3^−/− mice. Horizontal lines represent mean values.