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. 2005 Feb 21;201(4):579–590. doi: 10.1084/jem.20040876

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Copyright © 2005, The Rockefeller University Press

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Figure 4. — T_CM but not T_EM can mount a recall response after transfer and challenge. CD62L⁺ and CD62L⁻ cells were purified from the spleen and PLN of hosts transferred with naive β-tg CD8 cells and immunized at least 6 wk earlier (see Materials and methods) and equal numbers of D^b-Smcy3–specific T_CM (closed symbols) or T_EM (open symbols) were transferred into naive CD45.1⁺ female hosts that were immediately immunized with syngeneic CD45.1⁺ male bone marrow cells. (A) Evolution of the percentage of CD45.2⁺ transferred cells among host blood CD8 cells. The percentage observed at day 2 is normalized as 100%, and all subsequent percentages are expressed as a percentage of this standard. (B) Analysis of the percentage of D^b-Smcy3⁺ cells among blood CD8 cells. (C) Expression of the CD45.2 molecule by CD8⁺ D^b-Smcy3⁺ blood cells at day 15 or >1 mo after challenge, after transfer of naive, T_CM, or T_EM. (D) CD62L expression profiles and absolute numbers (in parentheses) of CD8⁺ D^b-Smcy3⁺ cells in organs of a CD45.1⁺ female host transferred with T_CM and challenged at least 6 wk before analysis. All results shown are representative of at least three experiments.