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. 2005 Feb 21;201(4):647–657. doi: 10.1084/jem.20041611

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Copyright © 2005, The Rockefeller University Press

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Figure 9. — TREM2 expression determines inflammatory response of microglia during phagocytosis of apoptotic neuronal material. Gene transcription of inflammatory mediators was analyzed by real-time RT-PCR of microglia cocultured with apoptotic neurons. Microglia were transduced with lentiviral vectors producing short hairpin RNAs specific for TREM2 (shTREM2), irrelevant short hairpin RNAs (shControl), wTREM2, control GFP2, mtDAP12 (mtDAP12-GFP), or control GFP1 vector. Relative level of gene transcripts for TNF-α, IL-1β, and NOS2 were increased in microglia transduced with the TREM2 knockdown vector compared with the control vector and decreased in microglia-overexpressing TREM2 compared with the control vector. Data are presented as mean ± SEM. *, P < 0.02; Mann-Whitney U test.