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. 2005 Aug 1;202(3):425–435. doi: 10.1084/jem.20041961

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Copyright © 2005, The Rockefeller University Press

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Figure 1. — Recruitment and activation of pDCs in inflamed LNs. (A) The frequency (top) and the absolute numbers (bottom) of B220⁺CD11c⁺ pDCs in PLNs (rt. PLN) from uninfected (d0) or HSV-infected mice on day 2 (d2). (B) Expression of CD86, CD40, and CD40L on blood pDC precursors from uninfected (d0) or HSV-infected mice on day 2 (d2). (C) Expression of CD86, CD40, and CD40L on LN CD11c⁺ DCs from uninfected (d0) or HSV-infected mice on day 2 (d2). The percentages of cells are indicated. (D) IFN-α production by sorted pDC precursors from HSV-infected mice on day 2 (pDCpre) and PLN pDCs from uninfected (LN pDC d0) or HSV-infected mice on day 2 (LN pDC d2) after 16 h of incubation with irradiated HSV. (A and D) Representative values from three independent experiments are presented as the mean ± SD (n = 6).