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. 2005 Aug 1;202(3):425–435. doi: 10.1084/jem.20041961

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Copyright © 2005, The Rockefeller University Press

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Figure 4. — Impaired APC function of LNDCs in pDC-depleted mice. (A) The number of IFN-γ⁺ spots produced by CD4⁺ or CD8⁺ T cells obtained from control PLNs on day 2, after 16-h incubations with the indicated numbers of DCs with no in vitro restimulation. DCs alone formed no spots. (B) The percentage of cluster-forming LNDCs from uninfected mice (d0), HSV-infected, control Ab–treated mice on day 2, and HSV-infected, anti-Ly6G/C Ab–treated mice on day 2. Indicated LNDCs were incubated for 2 h with LN CD3⁺ T cells from HSV-infected mice on day 2. T cells alone rarely formed clusters (<5%) in all groups tested. Representative data from three independent experiments are presented as the mean ± SD (n = 3). *, P < 0.05 by Student's t test, comparing mice treated with control or anti-Ly6C/G Ab.