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editorial

. 2005 Aug 1;202(3):341–344. doi: 10.1084/jem.20050221

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Copyright © 2005, The Rockefeller University Press

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Figure 1. — Negative selection checkpoints in B cell development. There are two points of BCR diversification—initial receptor rearrangement in the bone marrow and somatic hypermutation during the germinal center reaction. Each is followed by negative selection of autoreactive cells. Negative selection, receptor editing, anergy, or deletion occur in immature and transitional B cells after BCR engagement. The mechanisms for negative selection of autoreactive cells in GCs are not known. HC, heavy chain; LC, light chain.