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. 2005 Mar 21;201(6):1007–1018. doi: 10.1084/jem.20041442

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Copyright © 2005, The Rockefeller University Press

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Figure 6. — A46R and A52R target different TLR3-mediated signaling pathways. (a and b) HEK 293 cells were transfected with 0.5 ng TLR3 and the indicated amounts (ng) of either A52R or A46R, together with the NF-κB (a) or IRF3 (b) reporter plasmids as described in Materials and methods. Cells were stimulated with 25 μg/ml poly(I:C) 6 h before harvesting where indicated. Luciferase activity was measured after 24 h. Relative stimulation is shown on the y axis.