Skip to main content
. 2005 Mar 21;201(6):949–960. doi: 10.1084/jem.20041758

Figure 2.

Figure 2.

Silent fungal infections under non-SPF trigger arthritis in SKG mice. (A) PCRs of fungal 18SrDNA or mouse Rag 1 gene from esophagus (Es), lung (Lg), liver (Lv), or foot including ankle joint (Ft) of BALB/c or SKG mice in non-SPF. (B) Lungs of BALB/c or SKG mice in non-SPF or SPF were assessed for fungi by real-time quantitative PCR. (C–F) Methenamine silver (C and E) or hematoxylin and eosin (D and F) stainings of lungs from SKG mice (C and D) or BALB/c (E and F) of non-SPF. Arrows indicate argyrophilic fungal cysts. (G) Male SKG mice of 10 wk of age in the non-SPF facility were treated with four cycles of four daily i.p. injections of 75 μg amphotericin B (arrows) at 10-d intervals. (H) SKG mice in the SPF facility received the same protocol of antifungal treatment 10 d after i.p. administration of 2 mg zymosan (open inverted triangle). (I) Concentration of serum β-glucan in non-SPF or SPF 12-wk-old SKG mice.