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. 2005 Apr 4;201(7):1135–1143. doi: 10.1084/jem.20042614

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Copyright © 2005, The Rockefeller University Press

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Figure 8. — HMGB1-mediated I/R injury involves TLR4 system. (a) Hepatic TNF-α and IL-6 mRNA expression were obtained in TLR4-defective mice and wild-type mice after ischemia and 6 h of reperfusion. Mice were treated with anti-HMGB1 antibody or control antibody. Results are expressed as relative increase of mRNA expression compared with sham animals. Data represent means ± SE, n = four to six mice per group. *P < 0.05 versus TLR4 wild-type mice that were subjected to I/R and given control antibody. (b) Serum ALT levels were determined in TLR4-defective mice and wild-type mice after ischemia and 6 h of reperfusion. Animals were treated with recombinant HMGB1 or vehicle PBS immediately after reperfusion. Data represent means ± SE, n = four to six mice per group. *P < 0.05 versus TLR4 wild-type mice that were subjected to I/R and given vehicle PBS.