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. 2005 Apr 18;201(8):1293–1305. doi: 10.1084/jem.20040912

Figure 2.

Figure 2.

ChA6 mAb inhibits allogeneic and TT-specific proliferation of CD4+ T cells. (A) Primary MLR: CD4+ T cells were stimulated with allogeneic CD3-depleted cells with or without chA6 mAb (10 μg/ml). Results from one representative donor out of 14 are shown. Secondary MLR: CD4+ T cells were primed with allogeneic CD3-depleted cells for 10 d. Cells were collected and washed, and proliferative responses to the same allogenic cells used in the primary stimulation in the presence or absence of chA6 mAb (10 μg/ml) were tested. Results from one representative donor out of four are shown. Dose-dependent inhibition of primary MLR: CD4+ T cells were stimulated with allogeneic CD3-depleted cells in the presence of the indicated concentrations of chA6 or chimeric isotype control mAbs. Results from one representative donor out of five are shown. R, responder; S, stimulator. (B) TT response: total PBMCs were stimulated with TT with or without chA6 mAb (10 μg/ml). Results from one representative donor out of 16 are shown. The percentages of inhibition of proliferation in the presence of chA6 mAb relative to control are indicated.