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. 2005 Oct 3;202(7):975–986. doi: 10.1084/jem.20050421

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Copyright © 2005, The Rockefeller University Press

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Figure 3. — LPA inhibits CFTR-dependent I_sc in polarized epithelial cells and isolated mouse intestinal epithelia. (A) Representative traces of CFTR-mediated I_sc in response to ADO in HT29-CL19A cells without (top) or with (bottom) LPA 20:4 pretreatment. (B) I_sc in response to ADO in Calu-3 cells. DPC (500 μM) was used as a CFTR blocker toward the end of the experiment. (C) I_sc in response to ADO and cocktail (20 μM forskolin; 100 μM IBMX) in mouse intestinal epithelia. (D) Peak Cl⁻ currents (% control) activated by ADO or cocktail in mouse intestine epithelia summarized from (C) (n = 4).