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. 2005 Oct 3;202(7):975–986. doi: 10.1084/jem.20050421

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Copyright © 2005, The Rockefeller University Press

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Figure 4. — LPA inhibits CFTR-dependent Cl⁻ currents in a compartmentalized fashion. (A) Intracellular cAMP levels in Calu-3 cells under various conditions. (n = 4). (B) Single-channel recordings of CFTR in cell-attached configuration in HT29-CL19A cells under different recording conditions as indicated. C, channel closed state; FSK, forskolin; O, channel open state. (C) Summary of CFTR channel open probability (NPo). **P < 0.01; ***P < 0.001.