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. 2005 Oct 3;202(7):941–953. doi: 10.1084/jem.20050128

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Copyright © 2005, The Rockefeller University Press

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Figure 4. — Opposing roles of PGE₂ in the induction of CD83⁺/CCR7⁺/CD25⁺ DCs versus NK cells. Freshly isolated NK cells or TNF-α–activated monocyte-derived DCs were treated with IL-18, PGE₂, or their combination. (A) PGE₂ supports the induction of the chemokine receptor CCR7 on maturing DCs, but prevents the induction of CCR7 expression on IL-18–treated NK cells. Although IL-18 does not induce CCR7 expression on mature DCs, it does induce the expression of CCR7 and CD83 on NK cells. (B) PGE₂ prevents the acquisition of the migratory responsiveness to CCL21 in IL-18–primed NK cells. Data from one of three experiments that produced similar results.