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. 2005 May 2;201(9):1367–1373. doi: 10.1084/jem.20050572

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Copyright © 2005, The Rockefeller University Press

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Figure 2. — Reduced cellularity of lckCre Dicer ^Δ/Δ thymi, but no developmental block at the DN stage. (a) Thymocyte numbers and subset distribution defined by CD4 and CD8 expression in Dicer ^lox/lox and lckCre Dicer ^Δ/Δ littermates. The representation of thymocyte subsets and the total number of thymocytes are indicated. Note reduced cellularity in lckCre Dicer ^Δ/Δ thymi. (b) Expression of CD44 and CD25 on DN cells indicates normal DN subset distribution in lckCre Dicer ^Δ/Δ thymocytes. (c) Intracellular staining of DN thymocyte subsets indicates normal TCR-β expression in lckCre Dicer ^Δ/Δ DN thymocytes. (d) DNA content as assessed by propidium iodide (PI) staining indicates that lckCre Dicer ^Δ/Δ DN thymocytes proliferate normally. (e) TCR γδ-expressing cells are overrepresented in the absence of Dicer. (f) Genomic PCR shows that Dicer deletion is comparable, and virtually complete, in lckCre Dicer ^Δ/Δ γδ-expressing thymocytes.

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