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. 2005 Oct 17;202(8):1051–1061. doi: 10.1084/jem.20040662

Figure 3.

Figure 3.

Protection from colitis requires expression of CD103 by host cells. Mice received 4 × 105 CD4+CD45RBhigh T cells with 1 or 2 × 105 CD4+CD45RBlow or CD4+CD25+ T cells. (A) Colitis incidence in C.B.-17-SCID recipients of the indicated CD4 T cell populations. Antibodies were given i.p. twice weekly for 8 wk (0.5mg/injection). Data are pooled from four independent experiments. (B) Representative CD103 expression by CD4 T cells from WT animals (n = 8). The numbers shown indicate the percentage of cells in that gate. (C) Colitis incidence in C57BL/6-RAG−/− recipients of CD4+CD45RBhigh T cells and sorted CD103+ and CD103CD4+CD25+ cell subsets. Data are pooled from two independent experiments. (D) Cumulative colitis incidence in C.B.-17-SCID recipients after transfer of the indicated CD4 T cell subsets. Data are pooled from two independent experiments. (E) Colitis development in RAG−/− recipients of WT CD4 T cell subsets as indicated. Data are pooled from five independent experiments.