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. 2005 Jun 6;201(11):1781–1791. doi: 10.1084/jem.20041992

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Copyright © 2005, The Rockefeller University Press

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Figure 1. — OPN is increased in bone marrow with the activation of osteoblasts. Immunohistochemistry of tibia sections from wild-type (left) or littermate transgenic (right) mice with a constitutively activated PTH/parathyroid related peptide receptor driven by a 2.3-kb fragment of the collagenα1(I) promoter as previously described (reference 4). Sections were stained with antibody to osteopontin (red) and counterstained as described (reference 4), and photographed at 200× (top) with ∼4× image zoom (bottom). Yellow arrows indicate OPN-rich spindle shaped cells lining the trabecular bone that is consistent with an osteoblast morphology.