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Observed versus expecteda frequencies of change to modal residue at 16 sites not located in epitopes nor in envelope (E1 or E2) genes
| Expected | Observed | |
|---|---|---|
| Change to modal residue | 16b (1/19) = 0.8 ≈ 1 | 8b |
| Change to nonmodal residue | 16b (18/19) = 15.2 ≈ 15 | 8 |
Based on the null hypothesis that all amino acids are equally likely at each position.
P = 0.015.
