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. 2005 Jun 6;201(11):1805–1814. doi: 10.1084/jem.20050011

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Copyright © 2005, The Rockefeller University Press

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Figure 5. — T cell motility depends on the presence of antigen and MHC class II. T_OVA-GFP cells become stationary after intrathecal OVA injection. Live imaging of acute spinal cord slices 4 d after cotransfer of T_MBP and T_OVA-GFP cells. Left five bars: proportion of stationary T_OVA-GFP cells without manipulation (white bar) or 3 h after intrathecal injection of the control antigen BSA (cont. Ag), OVA, OVA plus isotype Ig control (OVA + cont. Ab), or OVA plus anti-MHC class II antibody (OVA + MHC II). Means ± SD of 412 cells from eight videos and five independent experiments. *P < 0.02; **P < 0.002. Right three bars: blocking anti-MHC class II antibody reduces the number of stationary T_MBP-GFP cells in the CNS. Proportion of stationary T_MBP-GFP cells in spinal cord slices 3 h after intrathecal injection of anti-MHC class II antibodies (MHC II, black bar). No manipulation (intact) or injection of isotype control antibody (cont. Ab) served as controls. Means ± SD of 320 analyzed cells. Video recording of six videos of three independent experiments (P < 0.001). Statistical significances were evaluated using Student's t test.