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. 2005 Jun 6;201(11):1725–1731. doi: 10.1084/jem.20042284

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Copyright © 2005, The Rockefeller University Press

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Figure 5. — Comparison of viral genetic sequence of donor, PD101, and PD102. (A) Dendrogram showing genetic relatedness of donor, PD101, and PD102 relative to other HCV isolates. Donor, PD101 (the sequence data are available from GenBank/EMBL/DDBJ under accession no. AY695436), and PD102 PD102 (the sequence data are available from GenBank/EMBL/DDBJ under accession no. AY695437) amino acid sequences were aligned against the corresponding sequences from the reference 1a isolate from which the peptides were derived (M62321), and a genotype 1b isolate (J4). The length of the horizontal lines connecting two isolates by the shortest route (right to left and left to right) is proportional to the genetic distance between the isolates. (B) Viral sequences for the prototype HCV-1 peptide sequence, donor, PD101 (6 mo after infection), and PD102 (1.5 mo) are shown; dashes indicate identity with the prototype and substitutions are represented by standard letter codes at different time points after infection. Known class I restricted epitopes are indicated in brackets [HLA A2 and B35].