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. 2005 Jun 6;201(11):1793–1803. doi: 10.1084/jem.20050085

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Copyright © 2005, The Rockefeller University Press

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Figure 8. — IL-7 and IL-15 counteract the suppressor activity of regulatory T cells and are present in synovial fluid of JIA patients. (A) Proliferation of CFSE-labeled CD4⁺CD25⁻ peripheral blood T cells stimulated by TSST-pulsed DCs in the absence (unshaded histograms) or presence (shaded histograms) of equal numbers of the CD4⁺CD25⁺ T cells. The cultures were set up in medium alone (no cytokines) or in medium supplemented with the indicated cytokines. (B) IL-7 and IL-15 were quantified by ELISA in sera and synovial fluid (SF) from 15 oligoarticular (white bars) and 15 polyarticular (gray bars) JIA patients and in sera from 12 age-matched healthy controls (black bars). Boxes contain values falling between the 25th and 75th percentiles. Lines that extend from the boxes represent the highest and the lowest values from each subgroup. The lines within the boxes represent median values. p-values were determined by Mann-Whitney U test.