Table II.

MCP-1^−/− mice suffer more severe neuropathology

	Pathological severity grade a
Genotype	(+)	(++)	(+++)
MCP-1− / − b	4c	10	6
C57BL/6J	5	15	0

Sections were assigned a severity grade in a blind fashion. Data represent five nonserial sections per mouse and four mice per genotype.

^aDistinguishing characteristics of severity grades are as follows: least severe (+), multifocal meningoencephalitis with minimal perivascular cuffing; intermediate (++), diffuse meningoencephalitis with more extensive perivascular cuffing; and most severe (+++), diffuse meningoencephalitis with cuffing the same as in (++), with necrotic foci, and loss of parenchyma.

^bSignificantly more likely to be found to have more severe pathology (Mann-Whitney U test; P < 0.05).

^cNumber of sections assigned to designated grade.