Figure 7.

Molecular networks linking proliferation and cell fate decision in HSC and progenitor cells. Summary of the proliferation index, phase of the cell cycle, and status of the cell cycle machinery associated with differentiation, self-renewal, or long-term engraftment capacity in HSC and progenitor cells. Several regulators of the cell cycle found to be specifically associated with maintenance of quiescence, differentiation, self-renewal, expansion, and mobilization are identified (underlined and bold). Such genes represent potential targets to encourage self-renewal, prevent differentiation, and reestablish quiescence during ex vivo expansion of HSC for clinical transplantation. They also represent potential targets for deregulation during leukemic transformation.