Table I.
Oligonucleotides (ONs)
| ON | Sequence 5′–3′ | Length | Position/description | S |
|---|---|---|---|---|
| 1170 | GGACUGCGUUCGCGCUUUCC | 20 | Stem/Loop IV | + |
| 1171 | GGCUUAUCCAUUGCACUCCGGA | 22 | Stem/Loop II | + |
| 1172 | GACUAGCUUGCUGUUU | 16 | 3′ Stem hY5 RNA | + |
| 1174 | UUUGUGGUAGUGGGGGACUG | 20 | Single-stranded region 5′ loop IV U1 RNA | + |
| 1176 | ACGAAGGUGGUUUUCCCAG | 19 | 3′ Stem I | + |
| 1177 | AAACAACAAACACACAAACC | 20 | U, G →A 1170 | − |
| 1271 | ACCUGGCAGGGGAGA | 15 | 5′ Stem I | − |
| 1272 | CCCAGGGCGAGGC | 13 | 5′ Stem II | − |
| 1274 | GGACUGCGUUGUGGCUUUCC | 20 | ORN 1170 with G/U-rich region | + |
| 1300 | GAUACUUACCUG | 12 | 5′ end U1 snRNA | + |
| 1302 | GAUACU | 6 | 5′ end U1 snRNA upon apoptotic cleavage | − |
| 1330 | AAUUUUUGA | 9 | Sm Site U4 snRNA | + |
| 1331 | AACCCCCGA | 9 | Sm Site U4 snRNA U to C | − |
| 1332 | AAUUUGUGG | 9 | Sm Site U1 snRNA | + |
| 1333 | AACCCGCGG | 9 | Sm Site U1 snRNA U to C | − |
| 1337 | GUAGUGUUUGUGGGGGACUG | 20 | ORN 1174 5′ UUUGUG shift center | + |
| 1338 | GUAGUGGGGGACUGUUUGUG | 20 | ORN 1174 5′ UUUGUG shift 3′ end | + |
| 1563 | GACUAGCCUUU | 11 | 3′ Stem hY3 RNA | + |
| 1668 (DNA) | TCCATGACGTTCCTGATGCT | 20 | Murine CpG B-Class | + |
| 1826 (DNA) | TCCATGACGTTCCTGACGTT | 20 | Murine CpG B-Class | + |
| 2006 (DNA) | TCGTCGTTTTGTCGTTTTGTCGTT | 24 | CpG B-Class | + |
| 2088 (DNA) | TCCTGGCGGGGAAGT | 15 | S-Class | − |
| 2216 (DNA) | GGG-G-G-A-C-G-A-T-C-G-T-CGGGGG | 19 | CpG A-Class (− indicates phosphodiester linkages) | + |
| 2395 (DNA) | TCGTCGTTTTCGGCGCGCGCCG | 22 | CpG C-Class | + |
All ONs have phosphorothioate backbones for nuclease resistance, except as indicated for ON 2216, and all are RNA with the exception of the last six, which are DNA as indicated. S + or − indicates stimulatory capacity of the ONs.