Figure 6.
T reg cell depletion before HDM sensitization increases the frequency of pulmonary mDCs. Mice were treated as in Fig. 5. Total number (A) and frequency (as a function of total lung cells) of mDCs (CD11c+, CD11b+, Gr1−; B) and total number (C) and frequency (as a function of total lung cells; D) of pDCs (CD11c+, CD11b−, Gr1+) were determined by flow cytometry. Data represent means + SEM (n = 12 mice/group). † or ††, P < 0.05 or P < 0.001, respectively, compared with HDM Iso/Iso–treated animals.