Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Dec 5;202(11):1587–1597. doi: 10.1084/jem.20051108

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2005, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 4. — Abnormal platelet function in Meg2^−/−mice. (A) Images of platelet aggregates in response to ADP and thrombin. (a and b) Platelet-rich plasma from Meg2^+/+ (a) and Meg2^−/− (b) hematopoietic progenitor cell–transplanted mice was treated with 20 μM ADP. (c and d) Washed platelets from Meg2^+/+ (c) and Meg2^−/− (d) hematopoietic progenitor cell–transplanted mice were treated with 1 U/ml thrombin. (d) Note that the platelet aggregates from wild-type hematopoietic progenitor cell–transplanted mice are substantially larger than those derived from Meg2^−/− mice. (B) Platelet aggregometry traces in response to thrombin and ADP. Left panel: platelet-rich plasma from Meg2^+/+ (black trace) and Meg2^−/− (gray trace) hematopoietic progenitor cell–transplanted mice was treated with thrombin to induce platelet aggregation. Platelet aggregation was measured by aggregometry after stimulation with 1 U/ml thrombin. Note the decreased thrombin-induced platelet aggregation in Meg2^−/− platelets. Right panel: Washed platelets from Meg2^+/+ (black trace) and Meg2^−/− (gray trace) hematopoietic progenitor cell–transplanted mice (black trace) were treated with 20 μM ADP. Meg2^−/− platelets demonstrate diminished platelet aggregation compared with Meg2^+/+ platelets.