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. 1998 Oct 19;188(8):1503–1510. doi: 10.1084/jem.188.8.1503

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B cell proliferation and Ig production after stimulation in vitro. Small dense B cells were prepared from the spleens of WT, TNF^−/−, and TNF/LTα^−/− mice and incubated in vitro with baculo-CD40L and varying doses of IL-4. (A) After 3 d, cell proliferation was measured by [³H]thymidine incorporation. (B) B cells were incubated for 7 d with baculo-CD40L and 100 U/ml IL-4. Concentrations of secreted IgM, IgG1, and IgE in the supernatant were measured by ELISA. Histograms in A and B depict mean ± 1 SD of triplicate determinations and are representative of two independent experiments.