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. 1998 Oct 19;188(8):1433–1443. doi: 10.1084/jem.188.8.1433

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Supernatants from activated PMN decrease endothelial paracellular permeability. Confluent HUVEC on permeable supports were exposed (apical surface only) to cell-free supernatants from activated (FMLP 10⁻⁶ M) PMN. Supernatants from activated PMN were added to monolayers. Supernatants, undiluted or diluted (as indicated) decreased transendothelial flux of FITC-dextran (*P < 0.05 vs. control [HBSS]; ANOVA). Supernatants (undiluted) decreased flux by 50 ± 7%. Data are from 10 monolayers in each condition. Results are expressed as mean reduction in permeability ± SEM.