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NECA pretreatment reverses the 5′-AMP– mediated decrease in endothelial paracellular permeability. Addition of 5′-AMP (50 μM) to HUVEC monolayers decreased transendothelial FITC-dextran flux (*P < 0.05 vs. HBSS). Pretreatment of HUVEC monolayers with NECA diminished ([NECA] = 300 nM) or abolished ([NECA] = 3 μM) this decrease in flux (‡ P < 0.05 vs. 5′-AMP without NECA). Data are from eight monolayers in each condition. Results are expressed as mean ± SEM.
