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. 1998 Oct 19;188(8):1391–1399. doi: 10.1084/jem.188.8.1391

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The apoptotic death resulting from stimulation with supraoptimal peptide–MHC determinant density is mediated by binding of TNF-α to TNF-RII. To determine whether TNF-α transduces the death signal via TNF-RI or TNF-RII, CTLs were stimulated with high (100 μM) or low (0.001 μM) concentrations of peptide in the presence of blocking antibodies to either TNF-RI or TNF-RII (each at 5 μg/well). Proliferation after stimulation with APCs pulsed with high concentrations of peptide antigen was restored only in the presence of antibodies to TNF-RII. The inability of the anti-TNF-RI antibody to prevent death was not due to an inability to block signaling through this receptor as this antibody could block TNF-α–mediated death in a TNF-α–sensitive L929 cell line (data not shown).