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. 1998 Oct 19;188(8):1391–1399. doi: 10.1084/jem.188.8.1391

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The apoptotic death of CTLs stimulated with high peptide– MHC determinant density can be blocked by caspase inhibitors. High avidity CTLs were stimulated with splenocytes either pulsed with 100 or 0.01 μM I10 peptide or unpulsed. BD-FMK or the control inhibitor (βZFA-FMK) was added at the indicated concentrations. Apoptotic nuclear morphology was assessed by staining with Hoechst 33342. The presence of BD-FMK during stimulation of CTLs with supraoptimal concentrations of peptide greatly inhibited apoptotic death. No inhibition of apoptotic nuclear morphology was observed with the control inhibitor, βZFA-FMK, which lacks the target aspartic acid.