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Selective serum immunodeficiency in HS1,2N/N and HS3aN/N mice but not in HS3aΔ/Δ or HS1,2Δ/Δ mice. Concentrations of specific immunoglobulin isotypes in sera from HS1,2N/N (open squares), HS3aN/N (open circles), HS3aΔ/Δ (closed circles), HS1,2Δ/Δ (closed squares) mice with their wt (closed triangles) littermates are shown. N represents the N/N mice, Δ represents the Δ/Δ mice, and WT indicates wild-type littermate controls. All isotypes except IgE were quantified by ELISA.
