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. 2000 May 1;191(9):1569–1580. doi: 10.1084/jem.191.9.1569

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Visualization of germinal centers in iFABP-IL7 Peyer's patches. Peyer's patches were dissected from the small intestine of age-matched control IL-7^+/+ mice (top) or iFABP-IL7 mice (bottom). 6-μm frozen sections were stained as described in Materials and Methods with mAbs that identified total B cells (B220⁺), total T cells (CD3⁺), naive B cells (IgD⁺), or germinal center B cells (GL7⁺). The iFABP transgene restored germinal centers to approximately the size visualized in normal mice, despite the concurrent deficiency in naive B cells.