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. 2000 May 1;191(9):1467–1476. doi: 10.1084/jem.191.9.1467

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Effect of HP-NAP on [Ca²⁺]_i in neutrophils in the absence or presence of pertussis toxin, wortmannin, PP1, and EGTA. (A) Human neutrophils loaded with Fura-2 for 25 min were washed and then exposed to the given concentrations of HP-NAP in a stirred fluorimeter cuvette. Fluorescence outputs were converted to [Ca²⁺] after calibration. (B) Only part of the increase in cytosolic [Ca²⁺] triggered by HP-NAP (solid line) is due to release from intracellular stores (broken line). (C) Pertussis toxin completely prevents the HP-NAP–induced rise in cytosolic [Ca²⁺], whereas other inhibitors are ineffective.