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. 2000 May 1;191(9):1611–1616. doi: 10.1084/jem.191.9.1611

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Histopathology of tarsal joints from FcRγ^+/+ and FcRγ^−/− DBA/1 mice 80 d after CII immunization. Severe arthritis was seen in FcRγ^+/+ mice (A) with inflammatory cellular infiltrate, invasive pannus, and erosions of cartilage and bone clearly detectable. The few FcRγ^−/− mice that developed disease (B) showed proliferation of synovial lining layer, synovial villi formation, but absence of cellular infiltrate and erosions. Joints of nonaffected FcRγ^−/− mice (C) were normal in appearance, with normal synovia and smooth intact cartilage. Representative sagittal paraffin sections with hematoxylin-eosin stain; original magnifications: (A) ×20; (B and C) ×50.