Figure 6.

Ribbon and surface diagrams of domain 1 of E-cadherin demonstrating the location of mutated residues. (A) Ribbon diagram of E-cadherin domain 1. The side chains of residues involved in adhesion to α_Eβ₇ are shown with stick diagrams in red. Mutation of side chains shown in blue did not diminish adhesion to α_Eβ₇ or diminished adhesion to α_Eβ₇ <20%. (B) Surface diagram of E-cadherin domain 1 in the same orientation as A. Residues involved in adhesion to α_Eβ₇ are shown in red, and residues that did not affect adhesion to α_Eβ₇ are shown in blue. (C) Surface diagram of E-cadherin domain 1 rotated ∼180° on a vertical axis from B.