Table 1.
Relative magnitude of sarcolemmal ion currents in models of male and female myocytes.
| Male | Female | |||||
|---|---|---|---|---|---|---|
| Epi | Mid | Endo | Epi | Mid | Endo | |
| INa | 1 | 1 | 1 | 1 | 1 | 1 |
| ICa,L | 1 | 1 | 1 | 1.32 | 1.32 | 1 |
| Ito | 1 | 1 | 0.5 | 0.75 | 0.75 | 0.375 |
| IKr | 1 | 1 | 1 | 0.83 | 0.83 | 0.83 |
| IKs | 1.42 | 1 | 1.42 | 1.42 | 1 | 1.42 |
| IK1 | 1 | 1 | 1 | 1 | 1 | 1 |
| INa,b | 1 | 1 | 1 | 1 | 1 | 1 |
| ICa,b | 1 | 1 | 1 | 1 | 1 | 1 |
| INaK | 1 | 1 | 1 | 1 | 1 | 1 |
| INaCa | 1 | 1 | 0.69 | 1 | 1 | 0.69 |
Values for subepicardial (epi), midmyocardial (mid), and subendocardial (endo) myocytes are relative to the current magnitude in the original Priebe-Beuckelmann model of a human ventricular myocyte.10
INa=fast sodium current, ICa,L=L-type calcium current, Ito=transient outward current, IKr=rapid delayed rectifier potassium current, IKs=slow delayed rectifier potassium current, IK1=inward rectifier potassium current, INa,b=background sodium current, ICa,b=background calcium current, INaK=sodium-potassium pump current, INaCa=sodiumcalcium exchange current.