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. 2000 Dec 18;192(12):1731–1744. doi: 10.1084/jem.192.12.1731

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Age-dependent changes in endothelium-dependent and -independent relaxation of the rat aorta. Line graphs showing concentration–response curves to acetylcholine (A), calcium ionophore A23187 (B), and SNP (C). Relaxation to both endothelium-dependent agonists was reduced in old aortas (P < 0.0001). Endothelium-independent relaxation was unaffected by age. M/L, mol/liter.