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. 2000 Dec 18;192(12):1731–1744. doi: 10.1084/jem.192.12.1731

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Age-dependent ·O₂ ⁻ production. (A) Bar graph showing both basal amount of chemiluminescence generated by ·O₂ ⁻ in aorta from young, middle-aged, and old rats (*P < 0.0001 versus basal values for young and middle-aged rats) and maximal generation of chemiluminescence after stimulation with calcium ionophore A23187 (10⁻⁶ mol/liter). (B) The influence of endothelium: aortic rings from young and old (n = 6 each) rats were mechanically denuded, and the basal chemiluminescence signal was compared with that from intact aortas.