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. 2000 Jun 5;191(11):1987–1998. doi: 10.1084/jem.191.11.1987

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Anti-CD28 Fab and anti–CTLA-4 F(ab′)₂ fragments can modulate the susceptibility of antigen-stimulated CD4 T cells to HIV-1 infection. (A) Before restimulation, TT-specific CD4 T cells were infected with an R5 strain (HIV_US-1) and stimulated with antigen-loaded DCs in the presence or absence of 25 μg/ml of anti-CD28 or anti–CTLA-4 fragments. Alternately infected cells were stimulated with CD3/28 beads. Supernatant p24 (in ng/ml) was measured 6 d after infection. (B) Cells were stimulated as in A and infected with X4 isolate HIV-1_NL4-3. Data shown are representative of two experiments.