Table 2. Allelic polymorphisms of thiopurine S-methyltransferse and their representative phenotypes.
Allele | Genotype | Phenotype |
---|---|---|
1 | wild-type | high metabolizer |
1A | C178T | high metabolizer |
1S | T474C | high metabolizer |
2 | G238C | intermediate metabolizer |
3A | G460A + A719G | intermediate metabolizer |
3B | G460A | intermediate metabolizer |
3C | A719G | intermediate metabolizer |
3D, 4–8, 10 | N/A | minimal effect |