TABLE III.
Burst Analysis for α4β2δ and α1β2γ2S GABAARs
τC1 (ms) [AC1] | τC2 (ms) [AC2] | τC3 (ms) [AC3] | τO1 (ms) [AO1] | τO2 (ms) [AO2] | τO3 (ms) [AO3] | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
α4β2δ | 10 mM THIP (n = 5) |
1.04 ± 0.47 [0.31 ± 0.10] |
14.9 ± 4.8 [0.69 ± 0.10] |
– | 1.76 ± 0.57 [0.49 ± 0.10] |
7.70 ± 2.03 [0.51 ± 0.11] |
– | |||||
10 mM THIP (n = 3) |
2.98 ± 0.31 [0.74 ± 0.06] |
18.3 ± 2.3 [0.26 ± 0.06] |
–
|
2.16 ± 0.70 [0.34 ± 0.11] |
6.76 ± 1.29 [0.66 ± 0.11] |
–
|
||||||
M–Mode (n = 10)
|
||||||||||||
α1β2γ2S | 10 mM GABA | 0.26 ± 0.02 [0.48 ± 0.03] |
1.12 ± 0.14 [0.31 ± 0.03] |
3.87 ± 0.41 [0.21 ± 0.03] |
0.49 ± 0.02 [0.26 ± 0.03] |
2.58 ± 0.09 [0.49 ± 0.04] |
5.17 ± 0.38 [0.25 ± 0.04] |
|||||
H–Mode (n = 5)
|
||||||||||||
0.34 ± 0.04 [0.58 ± 0.05] |
1.94 ± 0.22 [0.42 ± 0.03] |
– | 0.59 ± 0.11 [0.18 ± 0.02] |
4.22 ± 0.73 [0.41 ± 0.03] |
13.2 ± 2.6 [0.41 ± 0.05] |